UG3 |
Nerve Agent |
Identification and optimization of verapamil as a novel neuroprotective and anti-inflammatory agent for reducing long-term neurological morbidities following organophosphate-induced status epilepticus |
DESHPANDE, LAXMIKANT S |
VIRGINIA COMMONWEALTH UNIVERSITY |
---|
UG3 |
Nerve Agent |
Long-acting aldicarb hydrolase as a medical countermeasure for aldicarb poisoning |
ZHENG, FANG |
UNIVERSITY OF KENTUCKY |
---|
UG3 |
Vesicating Agent |
Development of small molecule inhibitors as anti-inflammatory agents and antidotes for arsenicals |
AUGELLI-SZAFRAN, CORINNE ELIZABETH |
SOUTHERN RESEARCH INSTITUTE |
---|
U54 |
Metabolic/Cellular Poison |
Advancing Novel Cyanide Countermeasures |
MACRAE, CALUM A |
BRIGHAM AND WOMEN'S HOSPITAL |
---|
U54 |
Nerve Agent |
UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate Intoxication |
LEIN, PAMELA J |
UNIVERSITY OF CALIFORNIA AT DAVIS |
---|
U54 |
Vesicating Agent |
Rutgers University CounterACT Center of Excellence |
LASKIN, JEFFREY D |
RUTGERS BIOMEDICAL AND HEALTH SCIENCES |
---|
U54 |
Vesicating Agent |
Barrier Damage and The Immune CascadeNorthwestern University CounterACT Center of Excellence (NUCCX) |
LU, KURT |
NORTHWESTERN UNIVERSITY AT CHICAGO |
---|
U54 |
Vesicating Agent |
UAB Research Center of Excellence in Arsenicals |
ATHAR, MOHAMMAD |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
---|
U01 |
Anticoagulant |
Optimization of Bile Sequestrants to Treat Superwarfarin Poisoning |
FEINSTEIN, DOUGLAS L |
UNIVERSITY OF ILLINOIS AT CHICAGO |
---|
U01 |
Metabolic/Cellular Poison |
Optimization of a Combined Drug and Delivery Device for Treatment of Cyanide Poisoning |
PATTERSON, STEVEN E |
UNIVERSITY OF MINNESOTA |
---|
U01 |
Nerve Agent |
Novel Counteract Agents To Reduce Mortality And Morbidity Following Organophosphate Status Epilepticus |
DESHPANDE, LAXMIKANT S |
VIRGINIA COMMONWEALTH UNIVERSITY |
---|
U01 |
Nerve Agent |
Advanced Development of Drugs to Mitigate Parathion Intoxication |
LASKIN, JEFFREY D |
RUTGERS BIOMEDICAL AND HEALTH SCIENCES |
---|
U01 |
Nerve Agent |
Novel Antibody-Oxime Pairing to Reduce Circulating Organophosphate Levels. |
THOMPSON, CHARLES MARK |
HUMAN BIOMOLECULAR RESEARCH INSTITUTE |
---|
U01 |
Nerve Agent |
Novel pediatric anticonvulsants for nerve agents |
REDDY, DOODIPALA SAMBA |
TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR |
---|
U01 |
Nerve Agent |
Novel Water-Soluble Adjunct Anticonvulsants for Nerve Agents |
REDDY, DOODIPALA SAMBA |
TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR |
---|
U01 |
Nerve Agent |
Saracatinib and 1400W Counteract Nerve Agents-Induced Long-Term Neurotoxicity |
THIPPESWAMY, THIMMASETTAPPA |
IOWA STATE UNIVERSITY |
---|
U01 |
Nerve Agent |
Antiglutamatergic Therapy to Protect the Brain Against Nerve Agents |
BRAGA, MARIA F |
HENRY M. JACKSON FDN FOR THE ADV MIL/MED |
---|
U01 |
Nerve Agent |
Optimization of Substituted Phenoxyalkyl Pyridinium Oximes as Therapies for Organophosphate Poisoning |
CHAMBERS, JANICE ELAINE |
MISSISSIPPI STATE UNIVERSITY |
---|
U01 |
Pulmonary Agent |
Optimization of AEOL10150 treatment of sulfur mustard-induced lung toxidrome in a pig model |
DAY, BRIAN J |
NATIONAL JEWISH HEALTH |
---|
U01 |
Pulmonary Agent |
Advanced TRPA1 Inhibitor for the Treatment of Chlorine Inhalation Injury |
JORDT, SVEN-ERIC |
DUKE UNIVERSITY |
---|
U01 |
Pulmonary Agent |
Antidotes against HCI-induced chronic lung injury |
CATRAVAS, JOHN D |
OLD DOMINION UNIVERSITY |
---|
U01 |
Pulmonary Agent |
Novel lead compound advancement for mitigating halogen-induced mortality and morbidity. |
AHMAD, SHAMA |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
---|
U01 |
Pulmonary Agent |
Identification of AMD3100 (Plerixafor) as a potential lead compound for chlorine toxicity |
AGGARWAL, SAURABH |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
---|
U01 |
Ultra-potent synthetic opioid |
Development of Agents for Synthetic Opioid Overdose |
PRISINZANO, THOMAS EDWARD |
UNIVERSITY OF KENTUCKY |
---|
U01 |
Ultra-potent synthetic opioid |
Antibody-based countermeasures against fentanyl and its analogues |
PRAVETONI, MARCO |
UNIVERSITY OF WASHINGTON |
---|
U01 |
Vesicating Agent |
Translation of novel and repurposed drugs to address the acute and late effects of mustard exposure |
LU, KURT |
NORTHWESTERN UNIVERSITY AT CHICAGO |
---|
U01 |
Vesicating Agent |
Targeted Therapeutic Approaches to Counteract Toxicity from Phosgene Oxime Skin Exposure |
TEWARI-SINGH, NEERA |
MICHIGAN STATE UNIVERSITY |
---|
U01 |
Vesicating Agent |
Optimization of Novel Molecular Target-based Drugs for Arsenical Skin Injury |
ATHAR, MOHAMMAD |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
---|
U01 |
Vesicating Agent |
Dexamethasone as an Effective Therapy for Ocular Injuries by Vesicating Agents. |
AGARWAL, RAJESH |
UNIVERSITY OF COLORADO DENVER |
---|
U01 |
Vesicating Agent |
Turbo Eye Drops to Treat Ocular Toxicity and Blindness from Sulfur Mustard |
MOHAN, RAJIV RAVINDRA |
UNIVERSITY OF MISSOURI-COLUMBIA |
---|
U01 |
Vesicating Agent |
First Aid Medicine to Treat Vesicant Induced Corneal Injury |
CHANDLER, HEATHER |
OHIO STATE UNIVERSITY |
---|
R56 |
Pulmonary Agent |
Mast Cell Activation as a Common Mechanism of Pulmonary Toxicity by Chemical Threat Agents |
BROWN, JARED MICHAEL |
UNIVERSITY OF COLORADO DENVER |
---|
R56 |
Pulmonary Agent |
Discovery of phosgene and chlorine gas modes of action and therapeutic targets using chemoproteomic profiling strategies |
LIN, VIVIAN S |
BATTELLE PACIFIC NORTHWEST LABORATORIES |
---|
R56 |
Pulmonary Agent |
Mechanisms underlying mustard gas-induced conjunctival injury and use of lipid mediators as medical countermeasures |
DARTT, DARLENE A |
SCHEPENS EYE RESEARCH INSTITUTE |
---|
R56 |
Pulmonary Agent |
Unraveling the corneal and retinal mechanisms of chemical injury |
MOHAN, ROYCE |
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT |
---|
R56 |
Pulmonary Agent |
Mechanistic Understanding of Mustard Gas Toxicity in the Retina using a Minipig Model |
CHAURASIA, SHYAM SUNDER |
MEDICAL COLLEGE OF WISCONSIN |
---|
R56 |
Ultra-potent synthetic opioid |
Identifying novel molecular targets, signaling pathways and mechanisms underlying fentanyl overdose-induced severe respiratory depression and lethality in rats using TMT phosphoproteomics/proteomics |
PAN, YING-XIAN |
RUTGERS BIOMEDICAL AND HEALTH SCIENCES |
---|
R56 |
Ultra-potent synthetic opioid |
Dissecting the central and peripheral mechanisms to fentanyl induced respiratory depression |
MORON-CONCEPCION, JOSE A |
WASHINGTON UNIVERSITY |
---|
R56 |
Vesicating Agent |
Extracellular vesicles as mediators of injury in inhaled exposures to toxic chemicals. |
AHMAD, AFTAB |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
---|
R34 |
Vesicating Agent |
The Role of Macrophages in Vesicant Skin Injury and Repair |
KOH, TIMOTHY J |
UNIVERSITY OF ILLINOIS AT CHICAGO |
---|
R34 |
Vesicating Agent |
The Initiation of Vesicant Skin Injury at a Single Cell Level |
ANDERSEN, BOGI |
UNIVERSITY OF CALIFORNIA-IRVINE |
---|
R34 |
Vesicating Agent |
Oxidized lipids and microvesicle particles as effectors for chemical threats to skin |
TRAVERS, JEFFREY B |
WRIGHT STATE UNIVERSITY |
---|
R34 |
Vesicating Agent |
Explant human skin perfusion model to study mechanisms of chemical injury and mitigation |
EJAZ, ASIM |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
---|
R21 |
Metabolic/Cellular Poison |
Treatment strategies for ocular toxicity from chloropicrin |
TEWARI-SINGH, NEERA |
MICHIGAN STATE UNIVERSITY |
---|
R21 |
Metabolic/Cellular Poison |
Hydrogen sulfide toxicity to the cornea |
MOHAN, RAJIV RAVINDRA |
UNIVERSITY OF MISSOURI-COLUMBIA |
---|
R21 |
Nerve Agent |
Refined uncharged Bis-Oximes for Rapid CNS Reactivation of OP-Inhibited hAChE. |
RADIC, ZORAN |
UNIVERSITY OF CALIFORNIA, SAN DIEGO |
---|
R21 |
Nerve Agent |
In Vivo Efficacy of Novel Uncharged Bis-Oximes in OP Poisoning Treatment |
RADIC, ZORAN |
UNIVERSITY OF CALIFORNIA, SAN DIEGO |
---|
R21 |
Nerve Agent |
Mitoapocynin, a novel NOX2 inhibitor, mitigates nerve agents induced longterm neurotoxicity |
THIPPESWAMY, THIMMASETTAPPA |
IOWA STATE UNIVERSITY |
---|
R21 |
Nerve Agent |
Converting human butyrylcholinesterase into a metalloenzyme for catalytic hydrolysis of organophosphates |
SHAFAAT, HANNAH S |
UNIVERSITY OF CALIFORNIA LOS ANGELES |
---|
R21 |
Nerve Agent |
High-throughput in vivo discovery of novel countermeasures against organophosphate-induced seizure and status epilepticus using zebrafish |
MCGRAW, CHRISTOPHER |
MASSACHUSETTS GENERAL HOSPITAL |
---|
R21 |
Nerve Agent |
Novel oxime antidotes for an organophosphate insecticide requiring bioactivation |
MEEK, EDWARD C |
MISSISSIPPI STATE UNIVERSITY |
---|
R21 |
Nerve Agent |
The role of adaptive immunity in organophosphate induced CNS injury |
ABDULLAH, LAILA |
ROSKAMP INSTITUTE, INC. |
---|
R21 |
Nerve Agent |
Novel behavioral screening tool for therapeutics against organophosphorus agents |
COLLINS, EVA-MARIA SCHOETZ |
SWARTHMORE COLLEGE |
---|
R21 |
Nicotine |
An Enzyme-Based Antidote for Acute Nicotine Toxicity |
JANDA, KIM |
SCRIPPS RESEARCH INSTITUTE, THE |
---|
R21 |
Pulmonary Agent |
Cationic CAMKIIN nanoparticles that reduce chlorine-induced airway oxidative stress |
SALEM, ALIASGER K |
UNIVERSITY OF IOWA |
---|
R21 |
Pulmonary Agent |
Repurposing thiosulfate for chlorine gas exposure |
DAY, BRIAN J |
NATIONAL JEWISH HEALTH |
---|
R21 |
Pulmonary Agent |
Cannabinoid-2 receptor signaling in vesicant induced lung injury |
NAGRE, NAGARAJA |
EASTERN VIRGINIA MEDICAL SCHOOL |
---|
R21 |
Pulmonary Agent |
Inhibition of soluble epoxide hydrolase protects against phosgene-induced lung injuries |
ACHANTA, SATYANARAYANA |
DUKE UNIVERSITY |
---|
R21 |
Pulmonary Agent |
Sickle Cell Trait Mice are More Susceptible to Chlorine Exposure and Haptoglobin Improves the Outcomes |
ALISHLASH, AMMAR |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
---|
R21 |
Ultra-potent synthetic opioid |
Restoring The Mechanical Properties of the Respiratory System as a Treatment of Fentanyl Overdose-Induced Hypoventilation using Kappa Agonists |
HAOUZI, PHILIPPE A |
CLEVELAND CLINIC LERNER COM-CWRU |
---|
R21 |
Ultra-potent synthetic opioid |
New brainstem targets for counteracting opioid induced apnea |
FELDMAN, JACK L |
UNIVERSITY OF CALIFORNIA LOS ANGELES |
---|
R21 |
Ultra-potent synthetic opioid |
Zebrafish Screens to Identify Agents which Reverse the Effects of Synthetic Opioids |
SCHIEFER, ISAAC T |
UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS |
---|
R21 |
Ultra-potent synthetic opioid |
Recruiting active expiration to overcome opioid-induced persistent apnea |
FELDMAN, JACK L |
UNIVERSITY OF CALIFORNIA LOS ANGELES |
---|
R21 |
Ultra-potent synthetic opioid |
Repurposing L-NAC to prevent fentanyl-induced respiratory depression |
LEWIS, STEPHEN JOHN |
CASE WESTERN RESERVE UNIVERSITY |
---|
R21 |
Ultra-potent synthetic opioid |
Synthetic Scavenger Medical Countermeasures for Fentanyl |
AVITAL-SHMILOVICI, MICHAL |
SRI INTERNATIONAL |
---|
R21 |
Vesicating Agent |
Development of a protein therapeutics to counteract mustard-induced skin injury |
LI, HAICHANG |
OHIO STATE UNIVERSITY |
---|
R21 |
Vesicating Agent |
Targeting Citrullination in Ocular Chemical Injury |
MOHAN, ROYCE |
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT |
---|
R21 |
Vesicating Agent |
Extracellular Vesicles derived from Mesenchymal Stem Cells as an Effective Medical Countermeasure against Mustard Induced Ocular Injury |
LEE, RYANG HWA |
TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR |
---|
R21 |
Vesicating Agent |
Antioxidant Eye Wash Formulations to Counter Ocular Chemical Threats |
LEBRUN, STEWART |
LEBRUN LABS, LLC |
---|
R21 |
Vesicating Agent |
Tissue Hypoxia and Topical Oxygen Therapy in Ocular Mustard Gas Injury |
YIN, JIA |
SCHEPENS EYE RESEARCH INSTITUTE |
---|
R01 |
Pulmonary Agent |
Halolipid-Neutrophil Extracellular Trap Axis in Halogen Lung Injury |
FORD, DAVID A |
SAINT LOUIS UNIVERSITY |
---|
R01 |
Pulmonary Agent |
Pulmonary cell fate and lung repair in rodent and porcine models of chlorine and phosgene inhalation injuries |
JORDT, SVEN-ERIC |
DUKE UNIVERSITY |
---|
R01 |
Pulmonary Agent |
Characterizing chemical threat agent exposures using a lung-on-a-chip platform and multi-omic analysis of common pathophysiological mechanisms |
MURPHY, SEAN VINCENT |
WAKE FOREST UNIVERSITY HEALTH SCIENCES |
---|
R01 |
Pulmonary Agent |
Pulmonary Pathophysiologic Mechanisms of Chloropicrin and Phosgene |
VAN WINKLE, LAURA S |
UNIVERSITY OF CALIFORNIA AT DAVIS |
---|
R01 |
Pulmonary Agent |
Pathophysiological Mechanisms of Chemical-Induced Acute Lung Injury |
LEIKAUF, GEORGE DOUGLAS |
UNIVERSITY OF CINCINNATI |
---|
R01 |
Pulmonary Agent |
Lipid and metabolic mechanisms responsible for phosgene and phosphorus trichloride exposure toxicity |
FORD, DAVID A |
SAINT LOUIS UNIVERSITY |
---|
R01 |
Pulmonary Agent |
Vascular injury and repair predict divergent late onset cardiovascular morbidities after chlorine and sulfur mustard exposure |
VERESS, LIVIA AGNES |
UNIVERSITY OF COLORADO DENVER |
---|
R01 |
Pulmonary Agent |
Mitochondrial DNA Injury is a Key Contributor to the Development of Chemical Lung Injury |
MATALON, SADIS |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
---|
R01 |
Ultra-potent synthetic opioid |
Transcriptomic single-cell profiling in breathing-specific parabrachial mu-opioid receptor neurons |
HAN, SUNG |
SALK INSTITUTE FOR BIOLOGICAL STUDIES |
---|
R01 |
Ultra-potent synthetic opioid |
Genetic Variation of Ultra-Potent Synthetic Opioid Sensitivity in Mice |
BUBIER, JASON A |
JACKSON LABORATORY |
---|
R01 |
Ultra-potent synthetic opioid |
Mechanism and Countermeasure of Carfentanil-induced Respiratory Disorder and Death |
XU, FADI |
LOVELACE BIOMEDICAL RESEARCH INSTITUTE |
---|
R01 |
Vesicating Agent |
The mechanism of vesicant-induced ocular injury |
GORBATYUK, MARINA |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
---|
R01 |
Vesicating Agent |
Toxic Mechanisms of Vesicating Chemicals in the Eye |
MCNUTT, PATRICK MICHAEL |
WAKE FOREST UNIVERSITY HEALTH SCIENCES |
---|
R01 |
Vesicating Agent |
Understanding Mustard Vesicants Distribution and Toxicity in the Eye Using In Vivo and In Silico Models |
TEWARI-SINGH, NEERA |
MICHIGAN STATE UNIVERSITY |
---|
R01 |
Vesicating Agent |
The Role of Master Epigenetic Regulators in Ocular Chemical Injury |
ZHANG, WENBO |
UNIVERSITY OF TEXAS MED BR GALVESTON |
---|
R01 |
Vesicating Agent |
Late/chronic corneal injury following threat chemical exposure |
MOHAN, RAJIV RAVINDRA |
UNIVERSITY OF MISSOURI-COLUMBIA |
---|
R01 |
Vesicating Agent |
Mitochondria and Mustard Damage at the Ocular Surface |
FINI, M ELIZABETH |
TUFTS MEDICAL CENTER |
---|
R01 |
Vesicating Agent |
Soluble epoxide hydrolase and epoxide fatty acid involvement in corneal injury after ammonia exposure: Mechanisms of injury and potential therapeutics using sEH inhibitors and biostable EpFA mimics. |
WATSKY, MITCHELL A |
AUGUSTA UNIVERSITY |
---|